Evaluation of heat shock protein 70(HSP-70) & heat shock protein 90(HSP-90) in diffuse large B-cell non-Hodgkin’s lymphoma patients
نور مصطفى علي
Authors :
Back ground: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized variability in clinical outcome, genetic features, and cells of origin. It is the most common lymphoid malignancy in adults, comprising almost 40% of all lymphoid tumors. Objective: To evaluate heat shock protein (70) & heat shock protein (90) in diffuse large B cell non-Hodgkin lymphoma patients. Patients and method: This is a case control study conducted during the period from (April 2015 to December 2015) on 55 patients (19 patients before treatment & 36 patients after treatment). Their ages ranged between 14 and 80 years and diagnosed to have diffuse large B cell non-Hodgkin lymphoma patients who attended the Baghdad teaching Hospital in medical city complex & Emmammain kadhimain medical city Hospital. In addition to control group consisted of 30 apparently healthy volunteer. Both patient and control groups were examined and reviewed clinically and assessed by basic laboratory investigation as well as measurement of heat shock protein (70) & heat shock protein (90) via Elisa technique. Results: HSP 70 showed a highly significant difference between patients and control groups (P value=0.001) as well as showed a highly significant difference (P value=0.001) between limited and advanced stage DLBCL. This difference is persistently reported in advanced disease patient whether before treatment or after treatment course (P value=0.001), as well as shown significantly (P value=0.014) in limited stage disease before and after treatment. HSP 90 shows significant difference between patients and control (P value=0.004) which is also highly significant difference (P value=0.001) for both limited and advanced stage as well as in relation to treatment courses (P value=0.001). Conclusion: HSP-70,HSP-90 are involved in pathogenesis of NHL in comparison with healthy people Which may indicate the abnormal cell growth and abnormal stability of tumor cells this may monitored and reduced after response to treatment. Keywords: DLBCL Heat shock protein 70 (HSP-70), Heat Shock Protein 90 (HSP-90), proteins, hormone receptors

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