Investigating the role of Toxoplasma gondii infection in diabetic patients type 2 diabetes mellitus
حيدر صباح كاظم
Authors : Qudus W.Jamal: Dept.of microbiology, Collage of medicine, AL-Nahrain University, Baghdad, Iraq Haider S. Kadhim: Dept.of microbiology, Collage of medicine, AL-Nahrain University, Baghdad, Iraq Mahmood S.K: Dep.of Medicine and Endocrinology, Collage of Medicine, AL-Nahrain University, Baghdad, Iraq
Abstract: Toxoplasma gondii is an obligate intracellular parasite that can cause variable clinical symptoms or can even be asymptomatic in immune-competent individuals. Both toxoplasmosis and diabetes are very common in Iraq, the present study aims to determine the possible relation between T2DM and Toxoplasm by detection and evaluating IgM and IgG Toxoplasma gondii antibody and investigating the level of C-peptide, HbA1C in diabetic patients whether infected or not infected with Toxoplasma gondii a case control study which was conducted on 180 patients with T2DM along with 40 healthy age and gender matched individuals who were included as healthy control. All patients were investigated for the presence of Toxoplasma gondii by Rapid chromatographic test and the titer was evaluated by ECLA (Electrochemiluesence Immunoassay). All samples whether positive or negative for toxoplasma, will be subjected for measuring HbA1C by Fluorescence Immunoassay (AFIAS), C-Peptide was evaluated by(ECLIA). This study showed that 42.2% of diabetic patients were infected with Toxoplasma gondii and 25% of apparently control healthy were infected with Toxoplasma gondii., moreover 46.4% of diabetic on insulin therapy were infected with T.gondii whereas 37% of diabetic on OHA were infected. Moreover IgG level was high, HbA1c was high and C-peptide was significantly low in insulin diabetic patients infected with Toxoplasma gondii.can be concluded that the incidence of T.gondii in Diabetic patients was higher than in control group thus we may predict that immune disturbance in diabetes had paved the way to Toxoplasma infection and highe IgG titer may be due to the parasite itself which had direct effect on Beta cell of the pancreas causing diabetes. Keywords Toxoplasmosis, C-peptid, T2DM, ECLA

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November, 2018.