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Detection and Genotyping of SEN virus (SEN-V) in Iraqi Patients with Hepatitis and Healthy Blood Donors
اروى مجاهد عبد الله
Authors : Ealaf A. Khudair, Arwa M. Al-Shuwaikh, Nawal M. Farhan
SEN virus (SENV) was discovered in 1999 as a DNA virus with hepatotropic properties. This study aims at determining the prevalence of SENV infection and genotypic characteristics in hepatitis patients and healthy blood donors. Serum samples were collected from 50 patients who had hepatitis B or C. In addition, 50 sera were collected from healthy blood donors as a control group. Serum samples were tested by nested polymerase chain reaction (PCR) for detection of SENV DNA and its two genotypes (SENV-H and SENV-D). SENV was detected in 42.0% (21 out of 50) of hepatitis patients versus 20% (10 out of 50) of controls. SENV-H was detected in a higher prevalence than SENV-D among cases and controls; 17 (81%) and 9 (90%), respectively, among cases and 4 (19%) and 1 (10%), respectively, among controls. The prevalence of SENV in hepatitis patients was significantly higher than in healthy blood donors. There was no statistically significant relationship between SENV positivity and the mean level of liver enzyme. Hence, infection with SENV was not associated with increased severity of liver disease even among HBV or HCV positive patients.

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2019