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CLINICAL AND BIOCHEMICAL ASSOCIATION BETWEEN SERUM AND URINE LEVEL OF THE UROMODULIN PROTEIN WITH ALBUMINURIA IN PATIENTS WITH TYPE-2 DIABETES MELLITUS
ريا سليمان بابان
Authors : Azher Abdulmutalib Ibrahim, Rayah Sulaiman Baban and Mahmood Shakir Khudair
This study aimed to investigate the correlation between uromodulin (THP) protein levels in serum and in urine with albuminuria and other renal function biomarkers in patients with type-2 diabetes mellitus. A case-control study design was employed to enroll 120 subjects, where 30 diabetic patients with normo-albuminuria (as first case group), 30 diabetic patients with microalbuminuria (as second case group), 30 diabetic patients with macroalbuminuria (as third case group) as well as 30 healthy subjects (as control group). Blood and urine samples were collected from the patients during their visits to diabetic clinics. Age, gender and BMI were assessed for each participant. Serum and urine uromodulin level were measured by ELISA technique, fasting serum glucose, serum creatinine and blood urea were measured by spectrophotometer, serum cystatin-c by ELISA technique, HbA1c measured by the CLOVER A1c system, urinary albumin was measured by turbidimetric end-point method, urinary uromodulin creatinine ratio (uromodulin index) and urinary albumin creatinine ratio (UACR) were estimated. Also, eGFR was calculated. The results show that the serum uromodulin was significantly and inversely correlated with FSG, also with HbA1c. A uromodulin indexwas significantly decline in macroalbuminuria group as compared with control group, also a uromodulin index was significantly decline in macroalbuminuria group as compared with normal bumiuria group. Uromodulin (Tamm-Horsful protein), which was specifically secreted from kidney, may considered as a marker changed in parallel with the change in renal function in patients with type-2 diabetic patients.

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19-10-2019