Salivary Levels of Neurotoxic Versus Neuroprotective Indices Underpin the Aberrant Response to Psychological Stress in Schizophrenic Patients
عدي خالد عبد الجبار
Authors : Mahmood A Nawfal, Hasan A Najat, Abduljabbar K Uday
Background: Schizophrenia is a chronic, recurrent disease that starts with a first psychotic episode and continues with periods of remission and acute psychosis with impaired interaction with stress. Aims: to allocate the gender differences in relation to distress in the salivary levels of the tryptophan (Trp), kynurenine (KYN) metabolites, cortisol and serotonin in patients with schizophrenia following psychological stress test. Methods: Eighty chronic schizophrenia patients and healthy controls, were subjected to a modified version of the Vienna test. Two saliva samples were gathered before and 10 minutes following stress test. Salivary concentration of cortisol, serotonin, Trp, L. KYN, Kynurenic acid (KYA), quinolinic acid (QUIN) and picolinic acid (PIC) were quantified by liquid chromatography triple quadrupole mass spectrometry. Results: Highly significant rise in the mean salivary post stress test cortisol concentration

(FULL ARTICLE LINK) Read more ...